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Dr Stuart Warriner is a Senior Lecturer in the School of Chemistry at the University of Leeds, part of the Faculty of Engineering and Physical Sciences. His research lies at the intersection of synthetic chemistry and biological systems, with a strong focus on developing chemical tools to probe and manipulate cellular processes.
His primary research interests include:
- Chemical Biology
- Synthetic Biology
- Organic Synthesis
- Mass Spectrometry
Dr Warriner's work centers on understanding and manipulating peroxisomal protein import pathways, particularly the PTS1 pathway, using synthetic probes and biophysical characterization. He also pioneers Activity Directed Synthesis—a novel method for discovering bioactive molecules by leveraging unpredictable chemical reactions and rapid screening. This approach bypasses traditional constraints in compound synthesis, enabling greater structural diversity in bioactive scaffolds.
His research has significant implications for synthetic biology, particularly in engineering orthogonal import systems to repurpose peroxisomes as customizable cellular compartments. These tools are being developed in moss cells and extended to other organisms.
Dr Warriner collaborates closely with Prof Alison Baker on peroxisome biology and with Prof Adam Nelson on Activity Directed Synthesis, reflecting a highly interdisciplinary approach. His laboratory employs advanced synthetic and analytical techniques, with a strong emphasis on mass spectrometry for compound characterization.
While no specific awards or publications are listed in the provided text, his ongoing projects indicate a vibrant and innovative research program with potential for future recognition and impact.
Dr Warriner advises students in chemical biology and synthetic chemistry, though specific advisees are not named. There is no indication of external grant funding in the text, but the scope of his work suggests involvement in funded research projects. His lab functions as an interdisciplinary team bridging chemistry and biology, focused on developing new methodologies for biological discovery and engineering.
