Stijn P. De Langhe

Stijn P. De Langhe, Ph.D., is a Professor at Mayo Clinic in Rochester, Minnesota, with appointments in the Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, and the Department of Biochemistry and Molecular Biology. His research is centered on lung regeneration, focusing on the molecular mechanisms of lung development and their role in diseases such as pulmonary fibrosis, COPD, asthma, and ARDS.

Dr. De Langhe’s research interests lie in understanding lung stem cell niche interactions, particularly the bidirectional signaling between epithelial and mesenchymal cells. His work emphasizes how developmental pathways like FGF10 and Hippo signaling are reactivated during injury and repair, and how their dysregulation contributes to fibrotic lung diseases. He explores processes including cell quiescence, proliferation, differentiation, migration, and survival in the context of lung regeneration.

The trends in his recent publications highlight a consistent focus on FGF10 signaling, epithelial-mesenchymal crosstalk, Hippo pathway regulation, and niche-mediated repair. His studies utilize mouse models and advanced techniques such as fluorescence in situ hybridization to investigate mechanisms of cell competition, bronchiolization, and alveolar epithelial regeneration in pulmonary fibrosis.

• Chair, 2nd Epithelial Mesenchymal Interactions in Lung Development and Fibrosis Conference, Fusion Conferences, 2022
• Chair, Epithelial Mesenchymal Interactions in Lung Development and Fibrosis Conference, Fusion Conferences, 2019

Dr. De Langhe has been a principal investigator on multiple NIH-funded research projects, including ongoing studies on cell competition in pulmonary fibrosis and ARDS, epithelial stem cell Hippo signaling, and FGF10-mediated epithelial-mesenchymal interactions. He has collaborated extensively with researchers across institutions and disciplines. His lab serves as a hub for investigating lung developmental biology and its implications for regenerative medicine. He has mentored numerous trainees and contributes to major scientific conferences in his field.