Steven Siegel

Steven Siegel is a faculty member at Boston Children's Hospital's Division of Infectious Diseases and an Instructor of Pediatrics at Harvard Medical School. His clinical focus includes immunocompromised pediatric patients, particularly those undergoing hematopoietic stem cell transplantation (HCT).

Dr. Siegel obtained his MD and PhD from the University of Pennsylvania (2014-2016), followed by pediatric residency in the Accelerated Research Pathway at Boston Children's Hospital (2018) and a fellowship in Pediatric Infectious Diseases (2022).

• University of Pennsylvania (Graduate School, 2014)
• University of Pennsylvania (Medical School, 2016)
• Boston Children's Hospital (Residency, 2018)
• Boston Children's Hospital (Fellowship, 2022)

His research investigates the gut microbiome's impact on pediatric HCT outcomes, addressing complications like infections and graft-versus-host disease (GVHD). He collaborates with Drs. Seth Rakoff-Nahoum and Leslie Kean to bridge knowledge gaps between adult and pediatric HCT microbiome studies.

Research Trends: Recent publications emphasize pneumococcal colonization mechanisms, host-pathogen interactions during viral-bacterial co-infections, and the role of innate immune signaling in pathogen transmission. Earlier work includes yeast cell biology, ribonuclease genetics, and eosinophil differentiation studies.

Scientific Awards:

• Pediatric Scientist Development Program Fellowship
• Boston Children's Hospital Office of Faculty Development Career Development Award

Dr. Siegel's work integrates clinical pediatrics with fundamental research on microbial pathogenesis, leveraging longitudinal microbiome studies in pediatric HCT patients to develop intervention strategies. His training spans immunology, microbiology, and translational medicine.