Steven M. Sine

Steven M. Sine, Ph.D., is a Professor of Pharmacology and Physiology at Mayo Clinic, holding primary appointments in the Department of Physiology & Biomedical Engineering. He is also a consultant in Neurology and Molecular Pharmacology and Experimental Therapeutics. His research focuses on neurotransmitter receptors' biophysical and molecular mechanisms, particularly nicotinic acetylcholine receptors in health and disease.

Education: BS in Biochemistry from University of California, Riverside; PhD in Pharmacology and Physiology from University of California, San Diego; postdoctoral training at Yale University and Salk Institute for Biological Studies.

Research Interests:

• Mechanisms of neurotransmitter receptor function and drug interactions
• Role of nicotinic receptors in neurodegenerative diseases, psychiatric disorders, and addiction
• Biophysical studies of muscle and neuronal nicotinic receptors

His lab uses advanced biophysical methods to study single receptor molecules and their structural dynamics.

Key Contributions: Over 160 publications, including work on congenital myasthenic syndromes and alpha7 nicotinic receptors' roles in cognition. His research impacts drug development for neurological disorders.

Awards:

• NIH Jacob Javits Merit Award (2001–2008)

Grants & Collaborations: Principal Investigator on NIH-funded projects studying nicotinic acetylcholine receptor structure and dynamics. Co-PI on the National Biomedical Computation Resource.