Steven Lisgo

Dr. Steven Lisgo is a developmental biologist and genomics researcher affiliated with Newcastle University. His research focuses on human embryonic and fetal development, with a strong emphasis on using single-cell RNA sequencing and spatial transcriptomics to map cellular and molecular processes across organs such as the brain, heart, skin, liver, and immune system.

Research Interests:

• Human developmental biology and embryogenesis
• Single-cell genomics and transcriptomics
• Neurodevelopment and cerebellar morphogenesis
• Immune system ontogeny and organogenesis
• Congenital malformations and genetic disorders
• Comparative developmental genomics across mammalian species

His recent publications (2020–2025) reflect a consistent trend toward creating comprehensive cell atlases of developing human organs, integrating multi-omics approaches to understand gene expression, cellular identity, and developmental trajectories. These studies often involve large-scale collaborations and utilize resources like the Human Developmental Biology Resource (HDBR).

Scientific Contributions & Collaborations:
Dr. Lisgo has co-authored numerous high-impact studies with collaborators such as Susan Lindsay, Rachel Botting, and Emily Stephenson, indicating his role in both research leadership and data generation. His work has contributed to understanding developmental disorders like holoprosencephaly, Down syndrome, and congenital heart defects.

Labs & Resources:
He is closely associated with the Human Developmental Biology Resource (HDBR), a UK-based initiative that provides human embryonic and fetal tissues for research, and is likely involved in managing or utilizing this resource for his studies.