Steven Lee

Professor Steven Lee is a leading figure in biophysical chemistry at the University of Cambridge, where he leads the TheLeeLab in the Yusuf Hamied Department of Chemistry. His research focuses on developing advanced single-molecule fluorescence and multidimensional super-resolution imaging techniques to probe fundamental biological processes at unprecedented spatial precision.

• Developed novel super-resolution microscopy approaches for 2D/3D visualization of T-cell membrane proteins and histone assembly in fission yeast nuclei
• Pioneer of 15-20nm resolution imaging strategies through fluorophore kinetics and image reconstruction algorithms

Recipient of the 2017 Marlow Prize in Physical Chemistry, Lee's lab produces cutting-edge tools with applications in immunology, neurodegeneration, and cellular biophysics. His team maintains active collaborations with Prof Klenerman (FRS MedSci) and Prof Moerner (Nobel Chemistry 2014).

• Research Highlights:
• Molecular origins of immunity through T-cell membrane protein interactions
• 3D histone dynamics during DNA replication/repair
• Amyloid aggregate quantification for neurodegenerative disease diagnosis
• Volumetric imaging innovations via vLUME virtual reality platform