معرفی
Steven Hahn is a Professor in the Basic Sciences Division at Fred Hutchinson Cancer Center (Fred Hutch), with an affiliate appointment as Professor in the Department of Biochemistry at the University of Washington School of Medicine. His research focuses on the molecular mechanisms of eukaryotic transcription, particularly the regulation of mRNA synthesis and the functional architecture of transcriptional machinery. Hahn’s work elucidates how transcription factors, coactivators, and RNA polymerase II complexes interact to initiate and regulate gene expression.
Education:
- PhD in Biochemistry, Brandeis University (1984)
- BA in Biochemistry, UC Santa Barbara (1979)
- Associate degrees, Santa Rosa Jr. College (1977)
Research Interests: Hahn’s lab investigates the molecular basis of transcription initiation, promoter recognition, and the roles of Mediator and SAGA complexes in regulating gene expression. Key areas include transcriptional noise, transcription factor-DNA interactions, and the structural organization of protein complexes like TFIID and RNA polymerase II.
Publications: Hahn’s recent work highlights discoveries in transcriptional regulation, including studies on transcription factor binding specificity, the role of Mediator in promoter recruitment, and structural insights into RNA polymerase II complexes. His research bridges biochemical, genetic, and structural approaches to unravel fundamental mechanisms in eukaryotic transcription.
Affiliations: Hahn’s primary affiliation is with Fred Hutch, where he leads the Hahn Lab. He collaborates extensively with the University of Washington and other institutions to advance understanding of transcriptional regulation in health and disease.
