Stephen Prince

Stephen Prince is a Lecturer at the University of Manchester, specializing in Membrane Protein Structural Biology. His research focuses on understanding the structure and function of integral membrane proteins, including Ion Channels, ABC transporters, and bacterial Outer Membrane Proteins, which are critical pharmacological targets.

• University: University of Manchester
• Academic Rank: Lecturer
• Research Themes: Structural Biology, Protein Biochemistry, Biophysics

Research Interests
Stephen investigates membrane proteins using recombinant expression technology and biophysical methods. His work addresses key protein families such as:

• Ion Channels: Studying conformational changes and interactions in excitable membranes.
• ABC Transporters: Exploring structural dynamics and substrate specificity, particularly in drug resistance proteins.
• Scaffold Proteins: Analyzing PDZ domains from Postsynaptic Density Protein 95 (PSD-95) and their role in organizing membrane receptors and channels.

Research Output Trends
His publications (28 total) emphasize structural biology techniques like X-ray crystallography, cryo-EM, and neutron scattering to study membrane protein interactions. Notable work includes collaborations on P-glycoprotein conformations and PDZ domain scaffolding mechanisms.

Projects
He contributes to a Structural Biology project focused on protein function and conformational changes, collaborating with researchers like A. Politis and R. Ford.

Network & Mentorship
Stephen has supervised 12 research works, indicating active involvement in mentoring students and junior researchers. His ORCID ID is 0000-0003-0929-0254.