معرفی
Stephen Joseph Elledge is an American geneticist and molecular biologist currently serving as the Gregor Mendel Professor of Genetics and Medicine at Harvard Medical School and Brigham and Women's Hospital. He has held academic positions at Stanford University, Baylor College of Medicine, and Howard Hughes Medical Institute since 1993. His research focuses on the genetic and molecular mechanisms of DNA damage response, cell cycle regulation, and viral infection detection.
- Doctoral advisor: Graham C. Walker (MIT)
- Doctoral thesis: Identification and characterization of genes involved in mutagenesis in Escherichia coli (1983)
Elledge's research has revolutionized understanding of DNA repair pathways and cell cycle checkpoints. His work spans protein kinases, ubiquitin-mediated degradation, and cancer genome evolution. He developed VirScan, a platform for detecting viral infections from blood samples, and contributed to identifying CDK2, CHEK1/2, and F-box motifs.
His 15 most recent articles cover topics in DNA damage response, yeast genetics, viral detection technologies, and cancer genome analysis. Notable trends include cell cycle regulation, ubiquitin pathways, and computational modeling of chromosomal abnormalities.
- NAS Award in Molecular Biology (2002)
- Breakthrough Prize in Life Sciences (2017)
- Albert Lasker Award for Basic Medical Research (2015)
- Canada Gairdner International Award (2013)
- Gruber Prize in Genetics (2017)
Elledge's lab at Harvard Medical School investigates DNA repair, viral serology, and cancer genetics. His work bridges fundamental biology with clinical applications, particularly in cancer and pandemic response.
