معرفی
Stephanie Schuller is an Associate Professor in Infection & Immunity at Norwich Medical School, University of East Anglia (UEA). She is a member of the Metabolic Health, Gastroenterology and Gut Biology, and Pathogen Biology Group research clusters. Her work is focused on understanding the molecular mechanisms by which pathogenic Escherichia coli strains interact with and disrupt the human intestinal mucosa.
Academic Background:
- PhD, University of Würzburg, Germany, 1997
- Diplom, University of Marburg, Germany, 1994
Her research interests lie at the intersection of microbiology, immunology, and gut health, particularly focusing on enteropathogenic (EPEC), enterohaemorrhagic (EHEC), enteroaggregative (EAEC), and adherent-invasive E. coli (AIEC). These pathogens are significant causes of infectious diarrhoea and are linked to conditions like Crohn’s disease. She employs advanced experimental models such as stem cell-derived intestinal organoids, vertical diffusion chambers (VDC), and human biopsy cultures under microaerobic conditions to mimic the gut environment and study host-pathogen interactions.
Her recent publications reveal a consistent focus on E. coli pathogenesis, toxin translocation, outer membrane vesicles, microbiome interactions, and the development of physiologically relevant infection models. Her work increasingly integrates complex systems like the microbiome and explores implications for inflammatory bowel disease and cancer.
Scientific Awards and Recognition:
- No specific awards listed in the provided text.
Dr. Schuller is an active mentor and supervisor, having led multiple PhD and MSc projects. She has secured significant research funding from the MRC, BBSRC, Wellcome Trust, and other bodies. She also contributes to the academic community through peer review for journals and funding agencies, and as an external examiner for MSc programs. Her teaching responsibilities include leading the Immunology theme in the MBBS program and serving as a tutor.
Laboratories and Research Teams:
She leads a research group at the Bob Champion Research & Education Building, focusing on microbe-host interactions. Her team collaborates on projects involving organoid models, microbiome studies, and bacterial pathogenesis, often in partnership with other institutions and researchers such as Prof. Le Gall and Prof. Troeberg.
