معرفی
Stephanie Heusser serves as an Assistant Professor in the Department of Drug Design and Pharmacology within the Faculty of Health and Medical Sciences at the University of Copenhagen. Her research focuses on the structural and functional characterization of acid-sensing ion channels (ASICs), with particular emphasis on their role in neurological disorders and potential as therapeutic targets. Based at Universitetsparken 2 in Copenhagen, she maintains an active research program integrating biophysical, pharmacological, and chemical biology approaches.
Her primary research interests center on acid-sensing ion channel mechanisms, including:
- Conformational dynamics during activation and desensitization
- Regulation by transporter proteins and peptide modulators
- Structural basis of pH sensing and ion selectivity
- Therapeutic targeting for pain, stroke, and neurodegenerative conditions
- Protein engineering approaches to study channel function
Dr. Heusser's work demonstrates substantial scholarly impact, with her 2021 review article in Trends in Pharmacological Sciences accumulating 35 citation indexes and 49 Mendeley readers, while being referenced in 15 X (Twitter) discussions and 1 Wikipedia page. Her research shows consistent high-impact output in premier journals including Nature Communications, eLife, and Cell Chemical Biology, with collaborative networks spanning multiple international institutions.
Her laboratory utilizes advanced techniques including:
- Protein semisynthesis for site-specific modifications
- Electrophysiological characterization of channel function
- Structural biology approaches to map conformational changes
- Pharmacological profiling of channel modulators
