Stephan Vagner

Stephan Vagner serves as Director of Research Unit Genome Integrity, RNA and Cancer (UMR3348) and Team Leader of RNA Biology, Signalling and Cancer (U1278) at Institut Curie in Orsay, while holding a professorship at Ecole Polytechnique since 2018. His leadership roles include Site Coordinator of the Research Center and Director of CNRS UMR3348/INSERM U1278 since 2020.

Dr. Vagner's research focuses on RNA regulations and RNA-binding proteins in cancer biology, with three primary axes: (1) DNA damage response mechanisms including intronic polyadenylation, (2) Tumor-intrinsic resistance to targeted therapies through mRNA translation reprogramming, and (3) Tumor cell-environment crosstalk in melanoma and leukemia. His work employs biochemical analyses, genome-wide RNA studies, and in vivo tumor models across cutaneous melanoma, breast cancer, and acute T lymphoblastic leukemia.

Analysis of his publication history reveals sustained expertise in translational regulation during therapy resistance, with recent emphasis on unconventional RNA-binding activities of metabolic enzymes and genotoxic stress responses. His collaborative network spans Institut Curie, CNRS, Inserm, and Ecole Polytechnique.

As Team Leader, he mentors researchers across multiple projects investigating RNA-protein interactions in cancer progression. His laboratory utilizes advanced techniques including RNA-seq, 3'seq, polysome profiling, and iCLIP for RNA-protein interaction studies.

The RNA Biology, Signalling and Cancer team operates within the Genome Integrity, RNA and Cancer unit, focusing on co-/post-transcriptional gene regulation in therapeutic contexts through biochemical, genomic, and phenotypic analyses.