Stephan Sigrist

Prof Dr Stephan Sigrist is a leading neuroscience researcher specializing in synaptic plasticity mechanisms, brain aging, and sleep regulation using Drosophila models. His work identifies key molecular players like Blobby in active zone assembly and Unc13 isoforms in sensory decoding. He explores mitochondrial-synaptic coupling in age-related resilience and autophagy-mediated neuroprotection.

Research Focus:

• Presynaptic nanoarchitecture and plasticity
• Sleep homeostasis and slow-wave oscillation networks
• Metabolic regulation of brain aging (spermidine, eIF5A-hypusination)
• Non-cell autonomous signaling in memory preservation
• Neural circuit adaptations in early aging

His recent publications (2019-2025) demonstrate consistent themes: 75% focus on synaptic mechanisms in aging/disease models, 50% investigate sleep-memory interactions, and 30% examine mitochondrial contributions. Methodologies combine super-resolution microscopy, electrophysiology, and genetic manipulation.