Stefan Bonn

Stefan Bonn is a researcher at the Institute for Medical Systems Bioinformatics (University Medical Center Hamburg-Eppendorf). With a focus on translational bioinformatics and computational systems biology, his work bridges machine learning with clinical applications in immunology, oncology, and neurodegenerative diseases.

• Key affiliations: Institute for Medical Systems Bioinformatics, UKE
• Selected methods: Multiomics analysis, Deep learning, Single-cell RNA-seq

Research spans autoimmune disease mechanisms (e.g., role of interferon signaling in kidney/liver diseases), cancer genomics (glioblastoma methylation patterns, melanoma mutation profiling), and neurogenetics (gamma motor neuron development, TDP-43 pathology in ALS). Current projects address precision medicine through genotype-based therapies and pathology informatics via novel imaging algorithms.

Recent publications demonstrate expertise in multiomics data integration (pytximport framework), deep learning for medical diagnostics (DeePSC for PSC detection), and single-cell immunoprofiling of inflammatory diseases. His computational tools like DISSECT and DISCERN improve cell type/subtype detection in complex datasets.

Collaborations span neurology, oncology, and immunology departments, with active roles in longitudinal studies of autoimmune conditions and cross-disciplinary AI development for healthcare applications.