معرفی
Sonia Caprio, MD is a Professor of Pediatrics (Endocrinology) at Yale School of Medicine. She serves in multiple roles including as a member of the Pediatric Endocrinology & Diabetes department, Diabetes Program, Diabetes Research Center, Liver Center, Obesity Research Working Group, Pediatric Weight Solutions Program, Yale Medicine, Yale Stress Center, and Yale Ventures. Dr. Caprio is a leading researcher in childhood obesity and type 2 diabetes with over 25 years of experience in patient-oriented research.
Dr. Caprio received her medical degree from Universita di Medicina e Chirurgia in 1978. She completed residencies at Ospedale Cardarelli (1980), Universita' di Medicina e Chirurgia (1980), and Temple University Hospital (1983), followed by a fellowship at Yale University School of Medicine (1989).
Dr. Caprio's research focuses on understanding the pathophysiology of childhood obesity and type 2 diabetes, with particular emphasis on insulin resistance and beta-cell dysfunction. Her work has demonstrated a faster progression of beta-cell failure in obese adolescents, which helped stimulate funding for major clinical trials like TODAY and RISE. She has assembled two large multiethnic cohorts: the Pathogenesis of Youth Onset Diabetes (PYOD) study and the Yale Pediatric NAFLD/NASH Cohort to investigate the roles of insulin resistance, beta-cell dysfunction and NAFLD in the earliest stage of T2D. Her research spans clinical and basic science in metabolism, genetics, and imaging.
Analysis of Dr. Caprio's most recent publications reveals a continued focus on metabolic disorders in youth, with particular attention to insulin resistance mechanisms, genetic factors in obesity, and treatment approaches for conditions like familial hypercholesterolemia. Her work spans basic science, clinical research, and translational applications, often examining how metabolic processes differ between youth and adults, and how these differences impact disease progression and treatment response.
- K24 Investigator Award in Patient Oriented Research (2001-2011)
- Bayer Scholar Award in Diabetes Research (2003)
- Distinguished Clinical Scientist Award, American Diabetes Association (2008-2012)
- Distinguished Leader in Insulin Resistance Award, International Committee for Insulin Resistance (2015)
- The Samuel J. Fomon Nutrition Award from the American Academy of Pediatrics (2017)
Dr. Caprio has served as Principal Investigator for multiple clinical trials including "Semaglutide Effects in Obese Youth With Prediabetes/New Onset Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease," "The Role of Hepatic De Novo Lipogenesis (DNL) in the Pathogenesis of Hepatic Steatosis," and "Children's Health Study to investigate adipocyte cell and lipid turnover in obese adolescents." She has also been a Sub Investigator for studies like "Preventing Obesity in Preterm Infants." Her research has been funded by NIH-NICD and other national and international organizations. Dr. Caprio emphasizes family-centered approaches to treating childhood obesity and diabetes, incorporating cutting-edge genetic testing to understand individual patient metabolism.
Dr. Caprio leads research teams focused on pediatric endocrinology and metabolism, with particular expertise in obesity, type 2 diabetes, and NAFLD in children and adolescents. Her work involves collaborations with researchers across multiple disciplines including genetics, imaging, and basic science to understand the complex mechanisms underlying metabolic disorders in youth. She is recognized for demonstrating the faster tempo of progression of beta-cell failure in obese adolescents, which has significantly influenced the field's understanding of youth-onset type 2 diabetes.
