Simon Kasif

Simon Kasif is a Professor of Biomedical Engineering at Boston University. He co-founded the Center for Advanced Genomic Technology (CAGT), COMBREX (Computational Bridges to Experiments), and is a member of the I2B2 Center. His work spans computational biology, systems biology, and AI applications in healthcare. He contributed to the Human Genome Project, co-developed tools like Glimmer and Mummer, and pioneered probabilistic networks for gene function prediction.

Education:

• M.S. & Ph.D., Computer Science, University of Maryland
• B.Sc., Mathematics, Tel Aviv University

Research Interests: Dr. Kasif focuses on integrating computational methods with biological data to understand disease mechanisms, particularly diabetes and cancer. His work emphasizes AI ethics, network biology, and translational research. He has developed methodologies for protein interaction networks, genomic data analysis, and systems biology modeling.

Key Contributions:

• Co-developed Glimmer, a widely used gene prediction tool
• Pioneered functional linkage networks for gene function prediction
• Advocated Bayesian networks in computational biology
• Investigated disease network signatures, including diabetes and Alzheimer’s
• Lead projects on AI safety, SARS-CoV-2 interaction mapping, and metabolic pathway analysis

Grants & Collaborations: Active in interdisciplinary projects, including the COMBREX initiative for protein function annotation and I2B2’s clinical data integration. His work bridges computational methods with clinical applications, fostering open science and reproducible research practices.

Labs & Teams: Directs research at CAGT and I2B2, collaborating across institutions to advance genomic technologies and systems biology approaches.