معرفی
Simon G. Mochrie is a Professor of Applied Physics and Physics at Yale University, leading the Mochrie Lab. His research focuses on applying physical techniques to study biological systems, including chromatin structure, protein degradation mechanisms, and nuclear mechanics. He develops advanced optical tools such as optical tweezers and STED microscopy to investigate molecular-scale biological processes.
Key research areas include:
- Single-molecule optical tweezers studies on nucleosomes and V(D)J recombination
- Development of fast-scanning STED microscopy to study the ubiquitin-proteasome system in yeast
- Investigation of peripheral chromatin's role in buffering cytoskeletal forces on the nucleus
His lab integrates instrumentation design with biological systems analysis, emphasizing super-resolution imaging and in vivo measurements. Current projects include probing proteasome dynamics and chromatin mechanics in living cells.
۰مقاله منتشرشده
