Silvia Fossati

Silvia Fossati is an Associate Professor at the Lewis Katz School of Medicine at Temple University, holding appointments in the Department of Cardiovascular Sciences, the Alzheimer's Center at Temple, the Lemole Center for Integrated Lymphatics and Vascular Research, and the Department of Neural Sciences. Her research is centered on the molecular mechanisms of neurodegeneration in Alzheimer’s disease, cerebral amyloid angiopathy (CAA), traumatic brain injury (TBI), and PTSD.

• PhD in Pharmacology and Toxicology, University of Florence, Italy
• Postdoctoral Fellowship in Pathology, NYU School of Medicine, New York, NY
• BS in Molecular Biology, University of Florence, Italy

Dr. Fossati's research focuses on mitochondrial dysfunction, oxidative stress, apoptosis, and blood–brain barrier integrity in the context of amyloid-β toxicity. She investigates how different amyloid variants trigger cell death in the neurovascular unit and explores pharmacological compounds, particularly carbonic anhydrase inhibitors, for neuroprotection. Her lab is actively discovering novel biofluid biomarkers for early diagnosis of AD, TBI, and PTSD.

Her recent publications (2015–2019) highlight consistent themes in mitochondrial pathology, amyloid-β oligomers, neurovascular apoptosis, and biomarker discovery, with strong translational implications for drug development and diagnostics. Key models include in vitro cultures, animal models, and human brain tissues.

Scientific Awards and Recognitions:

• Leon Levy Fellowship in Neuroscience (2016)
• Director, Biofluid Biomarkers Core, Cohen Veteran Center (2015–2019)
• Scientist Development Grant, American Heart Association (2013–2017)
• New Investigator Grants from Alzheimer’s Association and Blas Frangione Foundation

Dr. Fossati has served as a grant reviewer for the NIH, Alzheimer’s Association, US Department of Defense, Italian Ministry of Health, and others. She is a member of leading professional societies including the Society for Neuroscience, ISTAART, American Heart Association, and ISSNAF. Although no direct list of students is provided, her role as a lab director and corresponding author on multiple studies implies mentoring of graduate and postdoctoral researchers. She leads a multidisciplinary research team focused on cerebrovascular and neurodegenerative mechanisms.