Silvia Anna Synowsky

Silvia Anna Synowsky is a Research Fellow at the University of St Andrews' School of Chemistry and affiliated with the Institute of Behavioural and Neural Sciences. Her research focuses on quantitative proteomics, mass spectrometry, and the application of these techniques to study biological systems such as blood plasma proteins, gene therapy efficacy in mouse models, and extracellular vesicle immunopeptidomics. She collaborates extensively on projects involving enzyme catalysis mechanisms, metabolic disorder biomarkers, and soil proteomic workflows.

Her work contributes to UN Sustainable Development Goals related to health and innovation. Notable research areas include analyzing plasma protein alterations post-bariatric surgery, characterizing HLA-I immunopeptidomes in melanoma patients, and evaluating AAV9-mediated gene therapy outcomes in spinal muscular atrophy models. She is also engaged in improving soil metaproteomic methodologies to address organic matter interference challenges.

Dr. Synowsky actively contributes to collaborative projects such as 'Native Mass Spectrometry, the first steps' (2024-2025), co-led by Prof. Shirran. She has published 16 peer-reviewed articles and contributed to six datasets/software projects, including tools for SWATH-MS analysis and plasma protein binding studies.