Siegfried Janz

Siegfried Janz is a Professor at the Medical College of Wisconsin, affiliated with the Department of Medicine (Division of Hematology and Oncology) and the Cancer Center. His research specializes in multiple myeloma, leveraging molecular oncology, immunotherapy, and genetic studies to advance therapeutic strategies.

Dr. Janz investigates tumor microenvironments, drug synergies (e.g., FOXM1/BCL-2 inhibitors), CAR-T therapies, and mouse models of cancer. His recent work identifies prognostic biomarkers through genomic analyses and explores immune evasion mechanisms in myeloma.

His publications (2019-2025) predominantly focus on hematologic malignancies, with trends in:

• Immunotherapy development (bispecific antibodies, CAR-T)
• Genetic drivers of myeloma progression
• Preclinical validation of therapeutic targets
• COVID-19 outcomes in transplant patients