Shruti K Scott

Shruti K. Scott, DO is an Associate Professor at the Department of Medicine within the University of California, Irvine (UCI) School of Medicine. Her work focuses on hospital medicine and clinical research in autoimmune and renal disorders.

Her research explores the intersection of systemic lupus erythematosus, lupus nephritis, and complement-mediated thrombotic microangiopathies. A key publication highlights the therapeutic use of Eculizumab—a late complement inhibitor—in managing atypical Hemolytic Uremic Syndrome (aHUS) in the context of Class IV-G (A) lupus nephritis. This case study underscores the challenges in diagnosing aHUS, the limitations of plasma exchange in such cases, and the potential of complement inhibition strategies.

The clinical scenario described involves a patient with renal failure and hypocomplementemia who showed delayed cessation of hemolysis (detectable haptoglobin) after multiple doses of Eculizumab, despite initial platelet stabilization via plasma exchange. Her work emphasizes multidisciplinary approaches to complex autoimmune and renal pathologies.