Show-Ling Shyng

Show-Ling Shyng is a Professor at the Department of Chemical Biology and Biochemistry, School of Medicine, Oregon Health & Science University (OHSU). Her career spans multiple institutions within OHSU, including the Center for Occupational and Environmental Toxicology (1999-2008) and the Department of Biochemistry and Molecular Biology (2011-2019).

• Education:
  • B.S. in Zoology, National Taiwan University (1984)
  • Ph.D. in Neurobiology, Cornell University (1990)

Her research focuses on K ATP channel regulation in pancreatic beta-cells and cardiovascular systems, spanning structural biology, pharmacology, and disease mechanisms. Key contributions include elucidating ligand-mediated structural dynamics, pharmacochaperoning mechanisms, and trafficking regulation by Rab GTPases.

Recent publications highlight advancements in K ATP channel structural classification, AI-driven drug screening, and genetic mutations causing metabolic disorders. She has received the American Diabetes Association Career Development Award and secured NIH grants (R01 HL148609, R01 DK066485, etc.).

Her work bridges molecular mechanisms with therapeutic applications, particularly in diabetes and cardiovascular diseases, through collaborations across structural biology, pharmacology, and clinical endocrinology.