معرفی
Professor Sheila V Graham is a leading virologist at the University of Glasgow's Centre for Virus Research, where she holds the position of Professor of Molecular Virology. Her research focuses on human papillomavirus (HPV) and its connections to epithelial differentiation and cancer progression.
Dr. Graham's research interests span molecular virology, HPV life cycle mechanisms, RNA splicing regulation, and the development of biomarkers for HPV-associated diseases. Her work bridges basic molecular and cellular virology with clinical applications in HPV testing and therapeutics. She has made significant contributions to understanding how HPV regulates the innate immune response in keratinocytes and how viral infection leads to massive changes in the keratinocyte transcriptome.
Her recent publications reveal a strong focus on HPV-associated cancer mechanisms, RNA splicing factors in viral replication, and novel therapeutic approaches including microwave hyperthermia treatment. Her team has discovered that viral load serves as a positive predictor of survival in HPV-associated cancers and that microwaving can reverse tumor phenotypes by interfering with HPV gene expression.
Professor Graham has received substantial funding from major research councils including the Medical Research Council, Wellcome Trust, and Innovate UK for projects such as BioMARSC (RNA Biomarker Matrix for Risk Stratification of Cervical Disease) and MiTAG (Microwave treatment for anogenital disease).
She leads an active research group comprising PhD students, research assistants, and technicians, and collaborates with clinicians and researchers across Scotland and internationally. Her team has demonstrated that HPV represses keratinocyte immune responses and compromises epithelial barriers, while developing biomarker matrices that can risk-stratify HPV-associated cervical disease.
