معرفی
Dr. Shannon M Mumenthaler is an Assistant Professor of Research Medicine at the University of Southern California (USC), affiliated with the Department of Medicine and Biomedical Engineering. She holds a B.S. in Genetics from UC Davis and a Ph.D. in Cellular and Molecular Pathology from UCLA. Her research focuses on multidisciplinary approaches to cancer, combining computational modeling with experimental biology to study tumor evolution, drug resistance, and tumor microenvironment dynamics. She collaborates with mathematicians, engineers, and clinicians to develop tools for predictive oncology.
Her research interests include tumor-stromal interactions, organ-on-chip models, and circadian clock modulation in cancer therapy. She has pioneered methodologies like thin plate spline modeling for tumor invasion quantification and integrated metabolic imaging for therapeutic target screening.
Dr. Mumenthaler has received notable awards including the USC Medical Faculty Women’s Association Award (2013) and the NCI Junior Investigator Award (2013). Her work spans over 80 publications, with recent focus on colorectal cancer, GABAergic signaling, and patient-derived organoid systems. She leads efforts in computational oncology and biomimetic microenvironment modeling.
Her labs integrate advanced imaging (e.g., MALDI-MSI), machine learning, and mathematical modeling to predict drug responses and dissect cancer heterogeneity. Key contributions include elucidating how microenvironmental biomechanics influence metastasis and developing platforms to study fibroblast-driven therapy resistance.
