معرفی
Prof. Shana Sturla is a Full Professor at the Department of Health Sciences and Technology (D-HEST) at ETH Zurich. Her research focuses on understanding human toxicity through the lens of chemical structure-reactivity relationships, with a particular emphasis on dietary chemicals and nucleic acid interactions. Her work bridges toxicology, biochemistry, and molecular biology, aiming to elucidate mechanisms linking chemical exposure to cancer initiation and treatment.
Research interests include
- Mechanisms of mutagenesis via DNA-damaging agents
- Biomarkers for precision cancer therapy
- Safety assessment of nanomaterials
- Gut microbiota-mediated chemical toxicity
- Systems toxicology approaches for exposure modeling
Recent studies highlight her lab's work on DNA repair pathways (e.g., MGMT protein function), microbiome-driven metabolism of dietary carcinogens, and PBK modeling to predict internal exposure. Her interdisciplinary approach combines synthetic chemistry, bioanalytical techniques, and computational modeling to address translational toxicology challenges.
Key methodologies include
- Genome-wide DNA damage mapping
- In vitro-to-in vivo extrapolation
- High-content imaging for toxicity assessment
- Physiologically based kinetic modeling
No scientific awards or grants are explicitly listed in the provided text, but her extensive publication record reflects significant contributions to toxicology and cancer biology.
