Shahriar Mobashery

Shahriar Mobashery is the Navari Family Professor in Life Sciences at the University of Notre Dame, where he has been since 2003. He previously held academic positions at Wayne State University from 1989 to 2003, progressing from Assistant to Professor.

Education:

• Ph.D. in Chemistry (1985), University of Chicago
• B.S. in Chemistry (1981), University of Southern California
• B.S. in Biological Sciences (1980), University of Southern California

Research Focus: The Mobashery laboratory integrates computation, biochemistry, molecular biology, and organic synthesis to address critical clinical challenges. Key areas include:

• Elucidating mechanisms of resistance to β-lactam antibiotics in pathogens like MRSA and Pseudomonas aeruginosa
• Bacterial cell wall biosynthesis and recycling
• Discovery of novel antibacterials through enzyme inhibition studies
• Investigating extracellular matrix (ECM) dysregulation in diabetes, pulmonary fibrosis, traumatic-brain injury, and stroke

Publications Trends: Recent work focuses on structural characterization of bacterial enzymes (e.g., VldE, MltD, SleC) and their inhibition strategies. These studies span chemical biology, microbiology, and structural enzymology, particularly targeting antibiotic-resistant pathogens.

Scientific Recognition:

• Emil Thomas Kaiser Award (2019)
• Astellas USA Foundation Award (2007)
• Fellow of AAAS (2007) and Science Without Borders, Brazil (2014-2016)
• Charles H. Gershenson Distinguished Faculty Fellow (1999-2001)
• University of Notre Dame Research Achievement Award (2012)

Collaborative Network: Active in multidisciplinary research with collaborators like Prof. Juan A. Hermoso (structural biology) and Prof. James F. Fisher (antibiotic resistance). His lab works with graduate students on bacterial pathogenesis and ECM-related diseases.