Sergiu-Bogdan Catrina

Sergiu-Bogdan Catrina is an Associate Professor and Senior Physician at the Growth and Metabolism research group within the Department of Molecular Medicine and Surgery, Karolinska Institutet. His dual role bridges clinical practice and research in diabetes complications.

• Education:
  • Doctor of Philosophy (2005)
  • Docent (2012)

Research interests focus on molecular mechanisms of diabetes complications, particularly through:

• IGF-binding protein regulation (IGFBP-1)
• Oxidative stress and antioxidant therapies
• MicroRNA (e.g., miR-210) in glucose homeostasis
• Mitochondrial function in diabetic neuropathy
• Translational studies linking clinical observations to cellular mechanisms

Key article trends reflect investigations into:

• IGF/IGFBP system as diagnostic/prognostic tools
• Dietary and antioxidant interventions in diabetes
• Epigenetic modifications (DNA methylation)
• miRNA in insulin sensitivity
• Novel compounds for mitochondrial protection

Advising includes supervision of PhD candidate Camilla Olofsson, whose work examined fructose intake effects in type 2 diabetes.

Labs/Teams: Leads the Growth and Metabolism group, collaborating with researchers studying:

• Kerstin Brismar (IGF system in diabetes)
• Gustav Dallner (tocotrienol-based drug development)
• Michael Tekle (oxidative stress biomarkers)