معرفی
Sergi Garcia-Manyes is Professor of Biophysics at King's College London with a joint appointment between the Department of Physics and the Randall Division of Cell and Molecular Biophysics. He leads the Biological Physics and Soft Matter research group at King's and serves as a Principal Group Leader and Assistant Research Director at The Francis Crick Institute where he established a satellite laboratory in 2019.
Education:
- 2000: BSc in Chemistry, University of Barcelona
- 2005: PhD in Physical Chemistry, University of Barcelona (Scanning Probe Microscopy)
- Postdoctoral training: Columbia University (Biology Department) with Julio Fernández
Garcia-Manyes' research focuses on cellular mechanobiology, specifically how mechanical forces travel across cells to influence biochemical changes inside the nucleus. His laboratory develops and applies single-molecule techniques to capture the unfolding and refolding trajectories of proteins under force, combining concepts from polymer physics, protein chemistry, and molecular biology. His work addresses the fundamental question of whether phenomena observed in single-molecule experiments translate to cellular environments. Recent publications reveal his focus on nuclear mechanics, protein elasticity, and the role of mechanical forces in cellular processes.
Scientific Awards:
- EPSRC Early Career Fellowship
- Leverhulme Research Leadership Award
- Wellcome Trust Investigator Award
- Royal Society Wolfson Fellow
Garcia-Manyes holds significant research funding through his Leverhulme Research Leadership Award and Wellcome Trust Investigator Award, supporting his work on molecular mechanisms of cellular mechanobiology. His laboratory at the Crick Institute aims to understand how mechanical forces regulate cellular behavior, with implications for cardiovascular conditions and cancer. He collaborates extensively across institutions, including with Paula Booth from King's Chemistry and Justin Molloy from the Crick Institute.
The Garcia-Manyes lab operates across two primary locations: at King's College London where they maintain the Biological Physics and Soft Matter research group, and at the Francis Crick Institute where they established a satellite laboratory in 2019. The lab combines expertise in single-molecule biophysics, cell biology, and protein chemistry to investigate mechanotransduction pathways from the molecular to cellular level.
