Sergey Vakhrushev

Sergey Vakhrushev serves as Associate Professor in the Department of Cellular and Molecular Medicine at the University of Copenhagen's Faculty of Health and Medical Sciences. He leads the Vakhrushev Group, which focuses on proteome-wide characterization of O-glycan structures at specific sites in O-glycoproteins. His research addresses fundamental challenges in glycoproteomics through innovative methodological approaches.

Dr. Vakhrushev's primary research centers on post-translational modifications, particularly protein glycosylation. His group has made significant breakthroughs using genetically engineered 'SimpleCells' to overcome limitations in O-glycoproteome analysis, reporting over 15,000 O-glycosites and 5,000 O-glycoproteins. His work spans next-generation glycoproteomics, tyrosine O-GalNAc glycosylation, clinical glycoproteomics, and computational glycoinformatics. The research addresses critical challenges in simultaneous identification and quantification of native glycan structures on single glycosites, as well as glycosite occupancy and stoichiometry determination.

His recent publications demonstrate a strong focus on advancing glycoproteomics through methodological innovation with applications spanning basic science to clinical diagnostics. His work on aberrant glycosylation in cancer development shows particular promise for biomarker discovery. The research has significant implications for understanding biological functions in health and disease across multiple organ systems including liver, kidney, and brain.

Dr. Vakhrushev maintains an extensive international collaboration network spanning institutions in Zaragoza, Porto, Singapore, Muenster, Copenhagen, Split, Rome, Wien, and Athens. His research has garnered substantial attention, with publications being picked up by 72 news outlets, blogged by 3 sources, and widely shared across social media platforms including 39 X posts and numerous Bluesky references. His work has attracted significant academic interest with over 100 Mendeley readers across recent publications.