Sebastian Springer

Professor Sebastian Springer leads the Molecular Mechanisms of the Immune Response and Immuno-Biotechnology Research group at Constructor University Bremen. As a Professor of Biochemistry and Cell Biology in the School of Science since 2001, he investigates intracellular transport regulation of immune system membrane proteins, with a focus on MHC class I molecule dynamics and their role in pathogen detection and cancer immunosurveillance.

• University of California, Berkeley (Postdoctoral Fellow, 1996-2001)
• Oxford University (PhD, 1992-1996)
• Tübingen University (Diplom in Biochemistry, 1985-1992)

His research combines laser confocal microscopy with biochemical in vitro assays and biophysical approaches to study MHC class I peptide binding and surface localization. Key findings include demonstrating dynamic retention of empty MHC class I molecules and developing stabilized MHC variants commercialized through the Tetramer Shop (2019-21). Collaborations extend to biophysicists designing micrometer capsules for intracellular delivery.

Scientific achievements include the Ernst A.-C.-Lange-Preis, with publications covering MHC stability, peptide exchange mechanisms, and structural immunology. His group's work on micrometric capsule technology has both diagnostic and biotechnological applications.