Sean Mahase

Sean Mahase, MD is an Assistant Professor in the Department of Radiation Oncology at Penn State Cancer Institute. His work focuses on advancing radiation therapy techniques for brain metastases, head and neck cancers, and prostate cancer. He has published extensively on topics including stereotactic radiosurgery, multidisciplinary cancer care, and outcomes analysis between academic and community treatment settings.

Research Interests: Radiation oncology innovations, metastatic brain tumor management, and improving therapeutic strategies for lung and oropharyngeal cancers. His work contributes to UN Sustainable Development Goals related to reducing premature mortality from non-communicable diseases (SDG 3.4) and advancing health equity (SDG 3.8).

• Received 2024 Dean's Award for Excellence in Teaching
• Co-authored 33 peer-reviewed publications from 2011-2025
• Collaborations span international institutions in clinical oncology

Recent research highlights include:

• Developing staging subclassifications for HPV-associated oropharyngeal cancers
• Leading studies on brain metastasis risk prediction
• Pioneering multidisciplinary approaches for metastatic brain tumor patients

Engaged in clinical trials evaluating novel therapeutic combinations and radiation therapy protocols.