Scott Vandenberg

Scott Vandenberg, MD, PhD, is a Professor in the Department of Pathology at the School of Medicine, University of California, San Francisco (UCSF). He holds academic appointments in neuro-oncology, molecular pathology, and cancer biology. His research focuses on understanding tumor biology, therapeutic resistance mechanisms in glioblastoma, and biomarker discovery in cancer. He has led multiple NIH-funded grants, including initiatives on multiplexed imaging microscopy and tumor differentiation studies. His work bridges basic science and clinical applications, emphasizing translational research in oncology and neurology.

Education:

• B.S. in Zoology, Duke University, 1972
• M.D., Stanford University School of Medicine, 1979
• Ph.D. in Biochemistry and Behavioral Neurosciences, Stanford University, 1979

Research Interests: Dr. Vandenberg’s research integrates molecular pathology, tumor microenvironment analysis, and genomic approaches to study brain tumors and metastatic cancers. Key areas include glioma biology, immune checkpoint inhibitors, and mechanisms of drug resistance. His work leverages advanced technologies like multiplex immunofluorescence and single-cell profiling to dissect tumor heterogeneity and therapeutic targets.

Publications & Grants: Over 200 peer-reviewed publications highlight his contributions to cancer biology, including seminal studies on EGFR signaling in glioblastoma and biomarkers in breast cancer. He has served as Principal Investigator on NIH grants totaling millions, such as S10OD025187 (2018–2020) for imaging technology and R01NS022455 (1986–1990) on tumor differentiation. His findings have advanced clinical trials for targeted therapies and immunotherapies.

Labs & Collaborations: Collaborates with teams at UCSF’s Helen Diller Family Comprehensive Cancer Center and the Neuro-Oncology Program. His lab focuses on translational research, integrating pathology, genomics, and imaging to improve patient outcomes in high-grade gliomas and other CNS tumors.