معرفی
Dr. Satinder Kaur Singh is an Adjunct Associate Professor in the Department of Cellular & Molecular Physiology at Yale University School of Medicine. Her research focuses on the atomic-level mechanisms of neurotransmitter transporters, particularly serotonin (SERT) and dopamine (DAT) transporters, which are critical targets for antidepressants, antipsychotics, and illicit drugs.
- PhD in Biochemistry & Molecular Biophysics from University of Minnesota
- Postdoctoral training at Oregon Health and Science University and Columbia University
Her work combines X-ray crystallography, hydrogen-deuterium exchange mass spectrometry (HDX-MS), and molecular dynamics simulations to investigate transporter conformational changes, substrate/ion specificity, and antagonist binding sites. Current projects aim to elucidate disease-associated polymorphisms in OCD and depression while advancing structure-based drug design.
Key publications span 2014–2019, covering topics like paroxetine binding mechanisms, LeuT dynamics in lipid bilayers, and VMAT homologue functional residues. Awards include the NARSAD Independent Investigator Award and NIH K99/R00 Pathway to Independence Award.
- Email: satinder.k.singh@yale.edu
- Office: 333 Cedar Street, New Haven, CT
