معرفی
Dr. Saskia Overbeek is a Researcher in the Department of Pharmacology within the Faculty of Science at Utrecht University. Her research spans immunology, pharmacology, and nutritional science with a focus on how dietary components modulate immune responses and inflammation.
Dr. Overbeek's research interests include:
- Immune regulation through dietary components
- Human milk oligosaccharides and immune development
- Neutrophil biology in inflammatory conditions
- Gut-lung axis and mucosal immunity
- Microbiome-immune system interactions
- Development of nutritional interventions for immune-related disorders
Her publication record (2007-2024) demonstrates an evolution from neutrophil biology in respiratory diseases to broader investigations of dietary immunomodulation. Recent work (2018-2024) focuses on how human milk oligosaccharides and other prebiotics influence immune responses, particularly their ability to suppress Th2 responses while enhancing Th1 and regulatory pathways. This research has implications for allergy prevention, vaccine efficacy, and inflammatory conditions.
Key scientific contributions:
- Extensive publication record in high-impact journals including Nature Reviews Nephrology, PLoS One, and Gut
- Pioneering work on N-acetyl proline-glycine-proline and neutrophil-mediated inflammation
- Significant contributions to understanding gut-kidney axis in chronic kidney disease
- Research on how dietary components modulate immune responses in vaccination and allergy contexts
Dr. Overbeek has maintained extensive collaborations with researchers at Utrecht University, particularly with colleagues in pharmacology, immunology, and nutritional sciences. Her work typically employs in vitro models using intestinal epithelial cells and immune cells, complemented by murine models to study immune responses in vivo.
