Sarah W. Book

Sarah W. Book is a Professor at the Medical University of South Carolina's College of Medicine, Department of Psychiatry and Behavioral Sciences. She serves as Medical Director of the Center for Drug and Alcohol Programs and Director of the Clinical Neurobiology Laboratory, focusing on substance use biomarkers and treatment efficacy.

• Alcohol and Drug Addiction
• Mood and Anxiety Disorders
• Pharmacogenetics
• Clinical Neurobiology
• Medical Education
• Addiction Research Training

Dr. Book's research integrates clinical trials with biomarker analysis, evaluating medications like Mazdutide and TMP-301 for Alcohol Use Disorder. Her work bridges psychopharmacology with educational program development, aiming to enhance clinician-scientist training. Recent publications highlight her team's exploration of COMT regulation, sleep variability, and genetic predictors in addiction treatment.

Her clinical trials portfolio reveals trends in:

• Neuropharmacological interventions (e.g., tolcapone, gabapentin)
• Biological markers for substance use detection
• Integrated treatment models for dual diagnosis
• 12-step program effectiveness
• Medical student research engagement
• Postoperative pain management in addiction patients

Dr. Book mentors medical students, psychiatry residents, and addiction fellows, while leading interdisciplinary teams in Charleston, SC.