Sapna Das Bradoo

Dr. Sapna Das Bradoo is an Assistant Professor in the Natural Sciences Department at Northeastern State University (NSU) in Oklahoma. She holds a Ph.D. in Microbiology from the University of Delhi, India, and maintains an active research laboratory in the BA Science building (BASC133). Her work focuses on fundamental mechanisms of DNA replication with implications for cancer biology.

Dr. Das Bradoo's research centers on proteins involved in DNA replication, particularly the minichromosome maintenance protein 10 (Mcm10). Her laboratory employs biochemical, molecular biology techniques, and genetics using Saccharomyces cerevisiae as a model organism. Her key findings demonstrate that Mcm10 is di-ubiquitinated and plays a critical role in coordinating the switch between polymerase alpha and polymerase delta/epsilon during DNA replication. This work has important implications for understanding genome instability mechanisms that can lead to cancer development.

Analysis of Dr. Das Bradoo's publication record reveals a consistent focus on DNA replication mechanisms, particularly the role of Mcm10 and PCNA modifications. Her research spans multiple subfields including DNA damage response pathways, replication fork stability, Okazaki fragment processing, and S-phase checkpoint control. The work demonstrates how defects in DNA replication proteins trigger specific ubiquitination events that serve as alarm systems for genome instability.

Dr. Das Bradoo actively mentors both graduate and undergraduate students in her laboratory. Her students regularly present their research at regional and national conferences including the AAAS SWARM meeting, Oklahoma Academy of Sciences, and OK-INBRE Summer Undergraduate Research Conference. Several of her students have received awards for their presentations, including multiple first and third place prizes.

Her laboratory research is supported by NIH funding, specifically grants P41 RR001081/RR/NCRR and R01 GM074917/GM/NIGMS from the National Institutes of Health. Dr. Das Bradoo's work contributes to the broader scientific understanding of DNA replication mechanisms and their implications for cancer biology and potential therapeutic targets.