Santhi K. Ganesh

Dr. Santhi K. Ganesh is a tenured Professor of Internal Medicine and Human Genetics at the University of Michigan Medical School, where she holds the David J. Pinsky Endowed Professorship in Cardiovascular Medicine. She directs the M-BRISC initiative, focusing on sex differences in cardiovascular diseases. Her clinical expertise spans genetic cardiovascular disorders and vascular medicine, with research leveraging computational genomics and bench science to decode vascular pathologies.

Education & Training:

• MD: Northwestern University Feinberg School of Medicine (1997)
• BA: Northwestern University (1993)
• Residencies/Fellowships: University of Michigan, Johns Hopkins, NIH (NHLBI/NHGRI)

Research Focus: Her laboratory investigates the genetic architecture of vascular diseases including fibromuscular dysplasia, spontaneous coronary artery dissection, and hypertension. By integrating multi-omics data and disease modeling, her team identifies therapeutic targets for arterial dysplasias and sex-specific cardiovascular outcomes.

Publication Trends: Recent works (2025) emphasize molecular mechanisms of vascular remodeling, genetic risk prediction for atrial fibrillation, and translational insights into pregnancy-related cardiovascular disorders—consistently bridging genomics with clinical applications.

Awards & Honors:

• David J. Pinsky Endowed Professorship
• Recognition from American Heart Association
• Grants/Awards from Doris Duke Foundation and NIH

Leadership: Leads an NIH-funded research laboratory mentoring multidisciplinary trainees. Directs M-BRISC to advance understanding of sex-biased cardiovascular pathologies.