Samuel Gentle

Samuel Gentle, MD, is an Assistant Professor of Neonatology in the Department of Pediatrics at Yale School of Medicine. He is an attending neonatologist with a strong translational research focus on bronchopulmonary dysplasia (BPD) and its complications in preterm infants.

• Assistant Professor, Department of Pediatrics, Yale School of Medicine
• Member, Janeway Society
• Attending Neonatologist, Yale New Haven Children's Hospital

Education:

• MD, University of Alabama at Birmingham, 2012
• BS, Biology and Psychology, Loyola University New Orleans, 2006
• Residency, Icahn School of Medicine at Mount Sinai, 2015
• Fellowship, Neonatal-Perinatal Medicine, University of Alabama at Birmingham, 2018

Dr. Gentle's research centers on identifying mechanisms of BPD development and protective strategies to improve pulmonary outcomes in preterm infants. His work explores the role of nitric oxide bioavailability, including airway nitrite and oral nitrate reductase, as potential biomarkers and therapeutic targets. He also investigates the use of continuous biomedical signals—particularly oxygen saturation data—to detect and predict bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH), leveraging scalable NICU monitoring systems for early intervention.

His recent publications reflect a strong trend in both clinical neonatology and translational data science, with studies on permissive hypercapnia, teleneonatal resuscitation, and feeding dynamics in preterm infants. These works span randomized trials, quality improvement initiatives, and computational analyses, demonstrating a multidisciplinary approach to neonatal care.

Scientific Awards:

• Scholar Award, AAP/Vermont Oxford Network (2021)
• Young Investigator Award, SSPR (2024)

Dr. Gentle is actively involved in clinical research mentorship and has contributed to team science initiatives at Yale, particularly through the Janeway Society and collaborative projects with the Yale Center for Clinical Investigation (YCCI). He has not reported any major grants in the provided text but is engaged in NIH- and foundation-supported research environments. His work emphasizes innovation in neonatal monitoring, predictive modeling, and improving care delivery for vulnerable preterm populations.

He is a member of the Neonatal-Perinatal Medicine division within Pediatrics and collaborates closely with multidisciplinary teams focusing on lung injury, critical care, and neonatal outcomes. His lab or research group integrates clinical data with mechanistic studies to bridge bench-to-bedside applications in neonatology.