Saeed Tavazoie

Saeed Tavazoie is a Professor in the Departments of Biological Sciences, Systems Biology, and Biochemistry & Molecular Biophysics at Columbia University. His research focuses on developing innovative experimental technologies and computational tools for understanding gene regulation, protein-DNA interactions, and molecular networks in bacteria and yeast.

Education:

• Ph.D. in Biophysics, Harvard University (2000)
• M.D. training, Harvard-MIT Division of Health Sciences & Technology (1992-1995)
• B.S. in Physics, University of Utah (1992)

Research Interests:
Professor Tavazoie's work spans several key areas in molecular biology and systems biology. His lab develops cutting-edge technologies for global monitoring of protein-DNA interactions, including IPOD for bacterial systems and single-cell RNA sequencing methods. The research encompasses CRISPR-based genetic interrogation tools, high-throughput proteomic analysis methods, and computational frameworks for discovering regulatory elements. His work bridges experimental biology with computational approaches, creating comprehensive tools like FIRE for motif discovery and IGET for integrated genomic exploration.

Technological Contributions:
The Tavazoie Lab has developed numerous innovative tools including: IPOD (in vivo protein-DNA interaction monitoring), Yeast_CRISPRi (inducible CRISPR libraries for yeast), IVMD (in vivo mRNA display), PETRI-seq (bacterial single-cell RNA-seq), CALM (CRISPR-interference libraries), and various computational platforms like FIRE, TEISER, and ADAM for genomic analysis and evolution studies.

Contact Information:
Email: st2744@columbia.edu