Sabab Hasan Khan

Sabab Hasan Khan is a Postdoctoral Scholar in the Department of Biochemistry and Molecular Biology at Pennsylvania State University, affiliated with the Okafor Lab. His research focuses on structural and biophysical mechanisms of nuclear receptors, steroid receptors, and protein dynamics. He has contributed to understanding ligand-receptor interactions, evolutionary protein adaptation, and conformational changes in proteins under various conditions.

Key research interests include: evolutionary proteomics, structural biology of steroid receptors, allosteric networks in proteins, and molecular mechanisms of transcriptional regulation. His work integrates experimental techniques like X-ray crystallography with computational methods such as molecular dynamics simulations.

Recent publications highlight advancements in understanding androgen selectivity evolution, conserved allosteric networks, and structural stability of enzymes under extreme conditions. His studies also explore ancestral protein reconstruction and ancient ligand-sensing mechanisms.

Located in 408 Althouse Laboratory, he collaborates extensively on projects involving structural biology and biophysical characterization of proteins. His research has implications for drug design targeting nuclear receptors and understanding evolutionary adaptations in protein function.