Roy O. Mathew

Roy O. Mathew, MD is an Associate Professor in the Department of Medicine at Loma Linda University School of Medicine. His work bridges cardiology and nephrology, with a focus on cardiovascular-kidney-metabolic (CKM) syndrome, chronic kidney disease, and cardiovascular outcomes in high-risk populations.

His research interests include:

• Cardiovascular disease in diabetes and CKD
• Hypertension and podocyte health
• Lupus nephritis and IgA nephropathy
• SGLT2 inhibitors and cardiorenal outcomes
• Race-free eGFR and health equity
• Anticoagulation and lipid management in kidney disease
• Clinical trials (ISCHEMIA, ISCHEMIA-CKD)

Dr. Mathew has published over 120 articles, including recent high-impact reviews and original research in journals such as Circulation, JACC, and American Journal of Hypertension. His work emphasizes translational research, clinical guidelines, and population health, particularly in Adventist and veteran cohorts. He frequently collaborates with national research groups and contributes to American Heart Association scientific statements.

His scientific contributions include:

• Key insights into CKM syndrome
• Analysis of cardiovascular outcomes in dialysis and transplant patients
• Advocacy for race-free kidney function estimation
• Research on dietary patterns and chronic disease

Dr. Mathew is actively involved in federally funded and institutional research projects, including NIH-supported studies on cancer epidemiology in Adventists and cardiovascular risk in lupus nephritis. He serves as Principal Investigator and Co-Investigator on multiple grants, demonstrating sustained research leadership. His work is deeply integrated into clinical practice and policy development in cardionephrology.