معرفی
Romain Koszul is a Permanent Researcher and group leader at the Institut Pasteur in Paris, France, affiliated with the Department of Genomes and Genetics. He leads the research group focused on viral genome organization and dynamics, where he supervises PhD students, postdoctoral researchers, and engineers. His research is supported by prestigious European Research Council (ERC) grants, including the ERC Starting Grant (DICIG) and ERC Consolidator Grant (Synarchic), reflecting his leadership in the field of genome architecture.
His research focuses on the 3D organization of genomes, chromosome dynamics, and the development of computational tools for analyzing chromosome conformation data (Hi-C). He has pioneered the development of several widely used bioinformatics software packages such as Chromosight, instaGRAAL, Serpentine, and metaTOR, which enable high-resolution analysis of chromatin interactions, genome assembly, and metagenomic studies. His work bridges molecular biology, genetics, and computational genomics, with model systems including yeast (Saccharomyces cerevisiae) and bacteria.
The recent publication trend shows a strong emphasis on chromosome architecture, plasmid-chromosome interactions, epigenetic regulation, and the development of computational methods for genomics. His articles in top journals like Science, Nature, Cell Reports, and EMBO Journal reflect the interdisciplinary and high-impact nature of his research.
Scientific Awards:
- ERC Starting Grant (2010) – Project DICIG
- ERC Consolidator Grant (2017) – Project Synarchic
He actively mentors the next generation of scientists, with former PhD students and postdocs moving on to positions at institutions such as CNRS, EPFL, Oxford Biomedica, and NYU. His lab fosters a collaborative environment integrating experimental and computational approaches to understand fundamental aspects of genome biology.
Laboratories and Teams: He leads the 'Organisation et dynamiques des génomes viraux' research group within the Department of Genomes and Genetics at the Institut Pasteur. The team includes permanent researchers, postdoctoral fellows, PhD students, and engineers working on projects related to chromosome conformation, genome assembly, and microbial genomics.
