معرفی
Roger Sher is an Assistant Professor at the Renaissance School of Medicine, Stony Brook University. His research focuses on neurodegenerative diseases, particularly ALS, with three main themes: nuclear transport defects' role in neurodegeneration, interactions between genetics and environmental toxicants in ALS, and retrotransposons' impact on neuronal health. He uses mouse models, cell cultures, and biochemical analyses to explore these areas.
His lab, located in the Centers for Molecular Medicine, investigates how genetic mutations (e.g., NEMF, dynactin p150Glued) and environmental toxins contribute to disease progression. Key findings include identifying quantitative trait loci affecting ALS survival in mouse models and demonstrating triclosan's disruptive effects on mitochondrial structure.
Dr. Sher's work emphasizes interdisciplinary approaches, combining molecular genetics, cellular biology, and developmental biology. His recent studies highlight the potential of retrotransposon activation as a therapeutic target in ALS and the importance of ribosome-associated quality control in neuromuscular diseases.
