معرفی
Robert W. Sobol is a Professor at the Brown University in the Department of Pathology and Laboratory Medicine, and serves as the Associate Director for Basic Research and co-Leader of the Cancer Biology Program at the Legorreta Cancer Center. His research focuses on the DNA base excision repair pathway, Poly(ADP-ribose) polymerase (PARP) activation, and mechanisms of resistance to PARP inhibitors in cancer therapy.
- Key affiliations: Brown University, Warren Alpert Medical School, Legorreta Cancer Center
Research Interests include:
- Poly(ADP-ribose) signaling in DNA repair
- Genotoxic stress and replication stress responses
- Development of novel assays for DNA repair capacity
- Role of DNA repair in tumor resistance to chemotherapy and immunotherapy
Publications highlight work on:
- PARP and PARG inhibitors in glioblastoma
- Interplay between DNA repair and environmental pollutants
- Regulation of DNA polymerase beta in cancer and aging
- Identification of synthetic lethal interactions for precision oncology
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