Robert Koza

Robert Koza is a Faculty Scientist II at the MaineHealth Institute for Research and a faculty member of the University of Maine's Graduate School of Biomedical Science and Engineering. His research centers on molecular mechanisms of obesity and metabolic disease, with emphasis on epigenetic pathways and thermogenic energy expenditure.

Education:

• BS in Biology, North Adams State College, 1984
• MS in Biochemistry, University of New Hampshire, 1986
• PhD in Biochemistry, University of New Hampshire, 1989

Research Focus: Dr. Koza investigates non-genetic molecular drivers of obesity through his Epigenetics and Obesity Laboratory. Key work includes identifying the MEST gene's role in lipid storage and characterizing UCP1-independent thermogenesis. His research bridges epigenetics, adipose biology, and metabolic therapeutics, with implications for diabetes and cardiovascular disease.

Publication Trends: Analysis of his recent work reveals consistent exploration of adipose tissue regulation, featuring genes like MEST and CTHRC1, dietary interventions (methionine restriction), and alternative thermogenic pathways. Publications span molecular mechanisms to translational models, targeting obesity treatment strategies.

Leadership: He directs the MMCRI Summer Student Research Program and chairs the MMC Scientific Review Committee. Dr. Koza has extensive grant review experience for NIH (NIDDK, NIEHS), DOD, and NSERC (Canada).

Laboratory: The Epigenetics and Obesity Laboratory employs mouse models to study how genetic predisposition and environmental factors interact in metabolic disease, with current projects focusing on energy-expending mechanisms for obesity therapeutics.