معرفی
Dr. Robert Fagan is a Senior Lecturer in the School of Biosciences at the University of Sheffield, UK. His research focuses on understanding the molecular mechanisms of Clostridium difficile pathogenesis, particularly the role of the bacterial S-layer in host interactions, antimicrobial resistance, and virulence. He holds a PhD in Molecular Microbiology from Trinity College Dublin (2001-2005) and has extensive postdoctoral experience at Imperial College London (2005-2012). His work integrates molecular microbiology, structural biology, and genomics to study S-layer biogenesis, phage interactions, and antibiotic resistance pathways.
Research Interests: Dr. Fagan’s lab investigates how the C. difficile S-layer influences adhesion, immune evasion, and antibiotic tolerance. Key areas include S-layer structure-function relationships, phage receptor dynamics, and the evolutionary trade-offs in developing antibiotic resistance. His interdisciplinary approach combines cryo-electron microscopy, genetic screens, and in vivo models to dissect these mechanisms.
Publications: His recent work includes studies on vancomycin resistance pathways in C. difficile, structural analysis of S-layer assembly, and phage-host interactions. Notable findings highlight the S-layer’s dual role in both pathogenicity and bacterial survival in host environments.
Teaching: He coordinates advanced modules on bacterial cell organization and pathogenicity at the undergraduate level.
