Richard Locksley

Dr. Richard Locksley is a Professor at the University of California San Francisco (UCSF) in the Departments of Medicine and Microbiology & Immunology, and serves as Director of the Sandler Asthma Basic Research Center (SABRE). He trained at Harvard (B.A. in Biochemistry), the University of Rochester (M.D.), and UCSF (Residency, Chief Residency) before specializing in infectious diseases at the University of Washington. His career spans over 35 years at UCSF, including 18 years as Chief of the Division of Infectious Diseases.

Research Focus: The Locksley lab investigates the immune mechanisms underlying allergic (type 2) immunity, emphasizing interactions between T helper cells, innate lymphoid cells (ILC2s), and tissue-resident immune cells like eosinophils and mast cells. Key discoveries include the role of ILC2s in tissue homeostasis, mucosal adaptation, and metabolic regulation.

Scientific Awards & Honors:

• Howard Hughes Medical Institute Investigator
• Member of the National Academy of Sciences
• R37 MERIT Award, NIAID/NIH (2006)
• Ellison Medical Foundation Senior Scholar (2001-05)
• Association of American Physicians (1994)
• Bailey K Ashford Medal (1994)

Research Funding: Dr. Locksley has secured continuous NIH funding since 1988, including grants for asthma research (P01HL107202), parasite immunity (R01AI026918), and understanding asthma endotypes (U19AI077439). His work also includes training programs (T32AI007641) and explorations of epithelial-immune interactions.