Ram Mani

Ram Mani, Ph.D., is an Associate Professor in the Departments of Pathology and Urology at the University of Texas Southwestern Medical Center. He leads the Mani Lab, focused on understanding molecular and epigenetic mechanisms driving cancer development, with translational goals in diagnostics and therapeutics. His research integrates genomic, bioinformatic, and experimental approaches to study DNA damage pathways and transcriptional dysregulation in cancer. Dr. Mani holds prestigious awards, including the NIH K99/R00 Pathway to Independence Award and the Prostate Cancer Foundation's Young Investigator Award.

Education:

• Ph.D. in Human Molecular Genetics, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore
• Postdoctoral Training: Prostate Cancer Genomics & Epigenetics under Prof. Arul Chinnaiyan, University of Michigan

Research Focus: Investigates genomic rearrangements, DNA repair pathways, and epigenetic regulation in cancers like prostate and breast. Key areas include therapeutic resistance mechanisms, 3D genome organization, and tumor heterogeneity.

Awards:

• NIH K99/R00 Pathway to Independence Award
• Young Investigator Award (Prostate Cancer Foundation)

Lab & Collaborations: The Mani Lab, located on the 7th floor of the NB building, employs interdisciplinary teams to advance cancer research. Collaborations include the Harold C. Simmons Comprehensive Cancer Center and global institutions.