Rachel Smith

Rachel Smith is an Associate Professor in the Department of Psychological and Brain Sciences at Texas A&M University, affiliated with the Institute for Neuroscience (TAMIN). Her research focuses on the neurobiological mechanisms of drug addiction, particularly compulsive behaviors and relapse, using rodent models and advanced techniques like optogenetics and DREADDs. She investigates neural circuits involved in addiction, including the rostromedial tegmental nucleus (RMTg) and prelimbic cortex, and examines how these systems influence goal-directed versus habitual drug seeking.

Her work integrates behavioral paradigms, such as self-administration and punishment resistance, with anatomical tracing and pharmacological interventions. She explores how chronic drug exposure alters cognitive flexibility and neural plasticity in circuits like the striatum and thalamus. Smith’s lab employs cutting-edge tools to dissect the neurochemistry of addiction, aiming to identify novel targets for treatment development.

Recent studies emphasize the role of dorsal striatal subregions and thalamostriatal circuits in compulsive behaviors. Her findings highlight the interplay between habit formation and relapse triggers, with implications for understanding addiction as a chronic, relapsing disorder. Smith actively mentors students and accepts trainees for 2024–2025 research opportunities.