R. E. Schoen

R. E. Schoen is a Professor in the Division of Cancer Epidemiology at the German Cancer Research Center (DKFZ), affiliated with Heidelberg University's Medical Faculty. With 64 publications documented in the DKFZ database, Schoen maintains an active research program focused on the genetic and epidemiological aspects of colorectal cancer.

Schoen's research interests center on cancer epidemiology, particularly the genetics of colorectal cancer, Mendelian randomization studies, gene-environment interactions, and genome-wide association studies. Their work bridges population-level observations with molecular mechanisms to understand cancer etiology.

Analysis of Schoen's recent publications (2023-2025) reveals a strong focus on colorectal cancer risk factors, including adiposity relationships, gene-drug interactions with NSAIDs, molecular subtypes, and cross-ancestry genetic studies. The research employs sophisticated methodologies like Mendelian randomization and fine-mapping to establish causal relationships and identify biomarkers.

Schoen's scientific contributions include work on proteogenomic analyses identifying GREM1 as a mediator in adiposity-colorectal cancer relationships, fine-mapping studies identifying 136 putative colorectal cancer susceptibility genes across diverse populations, and investigations into how genetic risk modifies the protective effects of menopausal hormone therapy.

The research program demonstrates significant collaborative activity, with involvement in large international consortia including the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Schoen's work has substantial implications for cancer prevention strategies and personalized risk assessment approaches.